Company Profile

Heat Biologics Inc
Profile last edited on: 1/9/2019      CAGE: 58CA3      UEI: HQUBBMC377D4

Business Identifier: Cancer immunotherapies
Year Founded
2008
First Award
2010
Latest Award
2010
Program Status
Inactive
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Location Information

801 Capitola Drive Bay 12
Durham, NC 27113
   (919) 240-7133
   info@heatbio.com
   www.heatbio.com
Location: Single
Congr. District: 05
County: Forsyth

Public Profile

Heat Biologics, Inc. (NASDAQ: HBTX) is a biopharmaceutical company organzied around developing approaches to activate and co-stimulate a patient's immune system against cancer. The company's T-cell activating platform (TCAP) produces therapies designed to turn immunologically cold tumors hot and be administered in combination with checkpoint inhibitors and other immuno-modulators to enhance clinical effectiveness. The firm's TCAP product candidates include ImPACT platform technology that develops product candidates consist of live, allogeneic off-the-shelf genetically-modified, and irradiated human cancer cells; and Combination Pan-antigen Cytotoxic Therapy, a dual-acting immunotherapy designed to deliver T-cell activation and enhanced, and T-cell specific co-stimulation in a single treatment. The company is developing HS-110 that is in Phase 2 clinical trial in combination with Bristol-Myers Squibb's nivolumab (Opdivo) for the treatment of non-small cell lung cancer. Its preclinical trial product candidates include HS-130 for the treatment of non-muscle invasive bladder cancer; and PTX-35 and PTX-15 for treating tumors and hematologic malignancies. The company was founded in 2008 and is headquartered in Durham, North Carolina.offering ImPACT, an adjuvant technology to identify oncology and infectious disease indications. The firm is developing immunotherapies designed to activate a patient’s immune system against cancer using of CD8+ “Killer” T-cells. The firm's T-Cell Activation Platform (TCAP) produces therapies designed to turn “cold” tumors “hot” and be administered in combination with checkpoint therapies and other immuno-modulators to increase their effectiveness. HS-110 is Heat Biologics' first biologic product candidate in a series of proprietary immunotherapies designed to stimulate a patient’s own T-cells to attack cancer. The firm's ComPACT technology is the first potential, dual-acting immunotherapy designed to deliver T-cell activation and co-stimulation in a single product. Patients are currently (2018) being enrolled in Hat Biologics Phase 2 clinical trial for advanced non-small cell lung cancer, in combination with Bristol-Myers Squibb’s nivolumab (Opdivo®). Pelican Therapeutics, a subsidiary of Heat, is focused on the development of co-stimulatory monoclonal antibody and fusion protein-based therapies designed to activate the immune system. We also have numerous pre-clinical programs at various stages of development.

Extent of SBIR involvement

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Synopsis: Awardee Business Condition

Employee Range
20-24
Revenue Range
2M-2.5M
VC funded?
Yes
Public/Private
Publicly Traded
Stock Info
NASDAQ : HTBX
IP Holdings
25-49

Awards Distribution by Agency

Most Recent SBIR Projects

Year Phase Agency Total Amount
2010 1 NIH $300,000
Project Title: Development of Anti-Human Tl1a Monoclonal Antibody for the Treatment Of Human Asthma

Key People / Management

  Jeff Alan Wolf -- CEO and Founder

  Chin Christian -- CRA

  Vadim V Deyev -- Director of Applied Research

  Louise Giffin -- Research Scientist

  Anil Goyal -- Vice President of Business Development

  Jennifer Harris -- Vice President of Clinical and Regulatory

  Jeff Hutchins -- Chief Scientific and Operating Officer

  Padmini Jayaraman -- Business Development

  Janice Marie McCourt -- Vice President, Business Development

  Lori McDermott -- Vice President Clinical Development

  George Peoples -- Chief Medical Advisor

  Eckhard R Podack -- Chief Scientific Officer

  Ann A Rosar -- Vice President of Finance, Corporate Secretar

  Sandra Silberman -- Chief Medical Officer

  Gary Vinson -- Vice President, Chemistry, Manufacturing & Controls