
Ultra-high content analyses of circulating and solid tumor cells: A diagnostic reference system for disease burdenAward last edited on: 2/17/2024
Sponsored Program
SBIRAwarding Agency
NIH : NCITotal Award Amount
$1,913,568Award Phase
2Solicitation Topic Code
394Principal Investigator
Michel NederlofCompany Information
Phase I
Contract Number: 1R44CA250861-01A1Start Date: 8/16/2021 Completed: 7/31/2022
Phase I year
2021Phase I Amount
$223,653Public Health Relevance Statement:
PROJECT SUMMARY We propose to create a modular suite of products to facilitate highly multiplexed imaging and quantita- tive analyses of individual cells in intact tissue, and cells circulating in blood to be used to establish disease status. Our imaging software analyses platform supporting interactive data visualization will connect protein-based cellular features between tissue resident cells and disseminated cells to lever- age mechanisms of cancer cell dissemination to detect disease earlier, to identify risk for metastases, and to track response to treatment.
Project Terms:
Age; ages; Antibodies; Architecture; Engineering / Architecture; Biology; Blood; Blood Reticuloendothelial System; Malignant Neoplasms; Cancers; Malignant Tumor; malignancy; neoplasm/cancer; Rectal Cancer; Rectal Carcinoma; Rectum Cancer; Rectum Carcinoma; Cataloging; Cations; Cells; Cell Body; Color; Data Analyses; Data Analysis; data interpretation; Disease; Disorder; Foundations; Patient Care; Patient Care Delivery; Goals; Gold; Blood Tests; Hematologic Tests; Hematological Tests; Hematology Testing; Hybrid Cells; Somatic Cell Hybrids; Institutes; Maps; Methodology; Neoplasm Metastasis; Metastasis; Metastasize; Metastatic Lesion; Metastatic Mass; Metastatic Neoplasm; Metastatic Tumor; Secondary Neoplasm; Secondary Tumor; cancer metastasis; tumor cell metastasis; Oligonucleotides; Oligo; oligos; Oregon; Patients; Periodicity; Cyclicity; Rhythmicity; Phenotype; Proteins; Research; Risk; Signal Pathway; Signal Transduction; Cell Communication and Signaling; Cell Signaling; Intracellular Communication and Signaling; Signal Transduction Systems; Signaling; biological signal transduction; Computer software; Software; Specificity; Stains; Staining method; Technology; Testing; Time; Tissues; Body Tissues; Translations; Universities; Work; Immunofluorescence Immunologic; Immunofluorescence; symposium; conference; convention; summit; symposia; base; tumor progression; cancer progression; neoplasm progression; neoplastic progression; Blood specimen; Blood Sample; Label; Image Analysis; Image Analyses; image evaluation; image interpretation; Clinical; Phase; Biological; Link; Ensure; Evaluation; peripheral blood; Visual; Individual; Disease Progression; Solid Neoplasm; Solid Tumor; Collaborations; Indirect Immunofluorescence; Malignant Cell; cancer cell; tool; Malignant Pancreatic Neoplasm; Pancreas Cancer; Pancreatic Cancer; pancreatic malignancy; Malignant neoplasm of pancreas; Diagnostic; Complex; cell type; Pattern; System; Tumor Tissue; Operative Procedures; Surgical; Surgical Interventions; Surgical Procedure; surgery; Operative Surgical Procedures; early detection; Early Diagnosis; Tumor Cell; neoplastic cell; success; antibody conjugate; cohort; Primary Tumor; Primary Neoplasm; novel; validation studies; Abscission; Extirpation; Removal; Surgical Removal; resection; Excision; Sampling; protein expression; Address; Detection; Health Sciences; predict therapeutic response; predict therapy response; predict treatment response; therapy prediction; treatment prediction; treatment response prediction; Prediction of Response to Therapy; Cancer Patient; Small Business Innovation Research Grant; SBIR; Small Business Innovation Research; Tissue Model; Validation; Pathologic; Monitor; Process; Derivation procedure; Derivation; Development; developmental; Colorectal Cancer; Colo-rectal Cancer; cellular imaging; cell imaging; Image; imaging; burden of illness; burden of disease; disease burden; years of life lost to disability; years of life lost to disease; Population; cancer type; Cell model; Cellular model; spatial relationship; prototype; tumor; high risk; treatment response; response to treatment; therapeutic response; Biological Markers; bio-markers; biologic marker; biomarker; clinical assay development; colon cancer patients; colo-rectal cancer patients; colorectal cancer patients; targeted treatment; targeted drug therapy; targeted drug treatments; targeted therapeutic; targeted therapeutic agents; targeted therapy; personalized cancer therapy; individualized cancer therapy; personalized cancer treatment; imaging software; imaging platform; data visualization; biomarker panel; marker panel; biomarker identification; marker identification; prognostic assays; prognostic test; translational impact; multiplexed imaging; Visualization
Phase II
Contract Number: 4R44CA250861-02Start Date: 8/16/2021 Completed: 8/31/2024
Phase II year
2022(last award dollars: 2023)
Phase II Amount
$1,689,915Public Health Relevance Statement:
PROJECT SUMMARY We propose to create a modular suite of products to facilitate highly multiplexed imaging and quantita- tive analyses of individual cells in intact tissue, and cells circulating in blood to be used to establish disease status. Our imaging software analyses platform supporting interactive data visualization will connect protein-based cellular features between tissue resident cells and disseminated cells to lever- age mechanisms of cancer cell dissemination to detect disease earlier, to identify risk for metastases, and to track response to treatment.
Project Terms:
Age; ages; Antibodies; Architecture; Engineering / Architecture; Biological Assay; Assay; Bioassay; Biologic Assays; Biology; Blood; Blood Reticuloendothelial System; Malignant Neoplasms; Cancers; Malignant Tumor; malignancy; neoplasm/cancer; Rectal Cancer; Rectal Carcinoma; Rectum Cancer; Rectum Carcinoma; Cataloging; Cells; Cell Body; Color; Data Analyses; Data Analysis; data interpretation; Disease; Disorder; Foundations; Patient Care; Patient Care Delivery; Goals; Gold; Blood Tests; Hematologic Tests; Hematological Tests; Hematology Testing; Hybrid Cells; Somatic Cell Hybrids; Institutes; Maps; Methodology; Metastasis; Metastasize; Metastatic Lesion; Metastatic Mass; Metastatic Neoplasm; Metastatic Tumor; Secondary Neoplasm; Secondary Tumor; cancer metastasis; tumor cell metastasis; Neoplasm Metastasis; Oligo; oligos; Oligonucleotides; Oregon; Patients; Cyclicity; Rhythmicity; Periodicity; Phenotype; Proteins; Research; Risk; Signal Pathway; Cell Communication and Signaling; Cell Signaling; Intracellular Communication and Signaling; Signal Transduction Systems; Signaling; biological signal transduction; Signal Transduction; Software; Computer software; Specificity; Staining method; Stains; Technology; Testing; Time; Tissues; Body Tissues; Translations; Universities; Work; Immunofluorescence Immunologic; Immunofluorescence; symposium; conference; convention; summit; symposia; base; tumor progression; cancer progression; neoplasm progression; neoplastic progression; Blood specimen; Blood Sample; Label; Image Analysis; Image Analyses; image evaluation; image interpretation; Clinical; Phase; Biological; biologic; Link; Ensure; Evaluation; peripheral blood; Visual; Individual; Disease Progression; Solid Tumor; Solid Neoplasm; Collaborations; Indirect Immunofluorescence; Malignant Cell; cancer cell; tool; Malignant Pancreatic Neoplasm; Pancreas Cancer; Pancreatic Cancer; pancreatic malignancy; Malignant neoplasm of pancreas; Diagnostic; Complex; cell type; Pattern; System; Tumor Tissue; Operative Procedures; Surgical; Surgical Interventions; Surgical Procedure; surgery; Operative Surgical Procedures; early detection; Early Diagnosis; Tumor Cell; neoplastic cell; success; antibody conjugate; cohort; Primary Tumor; Primary Neoplasm; novel; validation studies; Abscission; Extirpation; Removal; Surgical Removal; resection; Excision; Sampling; protein expression; Address; Detection; Health Sciences; predict therapeutic response; predict therapy response; predict treatment response; therapy prediction; treatment prediction; treatment response prediction; Prediction of Response to Therapy; Cancer Patient; Small Business Innovation Research Grant; SBIR; Small Business Innovation Research; Tissue Model; Validation; Pathologic; Monitor; Process; Derivation procedure; Derivation; Development; developmental; Colorectal Cancer; Colo-rectal Cancer; cellular imaging; cell imaging; Image; imaging; burden of illness; burden of disease; disease burden; years of life lost to disability; years of life lost to disease; Population; cancer type; Cell model; Cellular model; spatial relationship; prototype; tumor; high risk; treatment response; response to therapy; response to treatment; therapeutic response; therapy response; Biological Markers; bio-markers; biologic marker; biomarker; clinical assay development; colon cancer patients; colo-rectal cancer patients; colorectal cancer patients; targeted treatment; targeted drug therapy; targeted drug treatments; targeted therapeutic; targeted therapeutic agents; targeted therapy; personalized cancer therapy; individualized cancer therapy; personalized cancer treatment; imaging software; imaging platform; data visualization; biomarker panel; marker panel; biomarker identification; marker identification; translational impact; multiplexed imaging; Visualization; prognostication; translational potential