
Preclinical development of a novel therapeutic for Parkinson's diseaseAward last edited on: 3/18/2025
Sponsored Program
SBIRAwarding Agency
NIH : NINDSTotal Award Amount
$3,421,621Award Phase
2Solicitation Topic Code
853Principal Investigator
Aarash BordbarCompany Information
Phase I
Contract Number: 1R44NS124398-01Start Date: 9/30/2021 Completed: 6/30/2022
Phase I year
2021Phase I Amount
$577,562Public Health Relevance Statement:
Project Narrative Levodopa is the primary treatment for Parkinson's Disease, a neurodegenerative disease that afflicts 1 million Americans. Unfortunately, levodopa has serious side effects and loses its efficacy over time. Using Sinopia Biosciences's computational drug discovery platform, we identified a small molecule that we subsequently tested and validated in relevant rodent and primate models, providing a unique mechanism for treating Parkinson's Disease. This proposal will complete preclinical drug development for this compound in order to advance to the clinic.
Project Terms:
Affect; inhibitor/antagonist; inhibitor; Biological Sciences; Biologic Sciences; Bioscience; Life Sciences; Brain; Brain Nervous System; Encephalon; Climacteric; life change; Discrimination; Cognitive Discrimination; Disease; Disorder; Dopamine; Hydroxytyramine; Pharmaceutical Preparations; Drugs; Medication; Pharmaceutic Preparations; drug/agent; Gene Expression; Germany; Gold; Half-Life; Human; Modern Man; In Vitro; Levodopa; L-Dopa; Literature; Metabolism; Intermediary Metabolism; Metabolic Processes; Liver Microsomes; Mus; Mice; Mice Mammals; Murine; Neurons; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; neuronal; Parkinson Disease; Paralysis Agitans; Parkinson; Parkinson's disease; Parkinsons disease; Primary Parkinsonism; Legal patent; Patents; Patients; Drug Kinetics; Pharmacokinetics; Pharmacology; Primates; Primates Mammals; Rattus; Common Rat Strains; Rat; Rats Mammals; Rodent; Rodentia; Rodents Mammals; Safety; Surveys; Survey Instrument; Testing; Time; Toxicology; Oxidopamine; 6-OHDA; 6-hydroxydopamine; Case Study; case report; Data Set; Dataset; base; dosage; improved; Acute; Chronic; Clinical; Penetration; Phase; Link; Lesion; disability; Funding; Agonist; MPTP Poisoning; 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine Poisoning; MPTP Neurotoxicity Syndrome; MPTP injury; MPTP lesion; MPTP lesioning; MPTP neurotoxicity; MPTP toxicity; MPTP-Induced Parkinsonism; toxic effects of MPTP; Therapeutic; Exposure to; machine learned; Machine Learning; Clinic; Pattern; Degenerative Neurologic Diseases; Degenerative Neurologic Disorders; Nervous System Degenerative Diseases; Neural Degenerative Diseases; Neural degenerative Disorders; Neurodegenerative Diseases; Neurologic Degenerative Conditions; degenerative diseases of motor and sensory neurons; degenerative neurological diseases; neurodegenerative illness; Neurodegenerative Disorders; meetings; American; Performance; mGluR4; metabotropic glutamate receptor 4; cognitive defects; Cognitive deficits; novel; behavioral test; behavior test; Position; Positioning Attribute; Gene Expression Monitoring; Gene Expression Pattern Analysis; Transcript Expression Analyses; Transcript Expression Analysis; gene expression analysis; gene expression assay; transcriptional profiling; Gene Expression Profiling; Modeling; Property; response; drug discovery; Neural Stem Cell; neural precursor; neural precursor cell; neural progenitor; neural progenitor cells; neuron progenitors; neuronal progenitor; neuronal progenitor cells; neuronal stem cells; neuroprogenitor; nerve stem cell; small molecule; Dose; Symptoms; Data; Pre-clinical Drug Testing/Development; Preclinical Drug Testing/Development; pre-clinical drug development; Preclinical Drug Development; Motor; in vivo; Pharmacological Treatment; Cardiac; Adjuvant; Development; developmental; preclinical study; pre-clinical study; Gene Expression Profile; Expression Signature; gene expression pattern; gene expression signature; transcriptional profile; transcriptional signature; older patient; elderly patient; novel therapeutics; new drug treatments; new drugs; new therapeutics; new therapy; next generation therapeutics; novel drug treatments; novel drugs; novel therapy; effective therapy; effective treatment; preclinical efficacy; pre-clinical efficacy; candidate selection; L-DOPA induced dyskinesia; Levodopa dyskinesia; levodopa induced dyskinesia; Secure; cognitive testing; cognitive assessment; cognitive task; symptom treatment; symptomatic treatment; treat symptom; motor symptom; efficacy study; clinical development; preclinical development; pre-clinical development; computational platform; computing platform; side effect; motor behavior
Phase II
Contract Number: 4R44NS124398-02Start Date: 9/30/2021 Completed: 2/28/2025
Phase II year
2023Phase II Amount
$2,844,059Public Health Relevance Statement:
Project Narrative Levodopa is the primary treatment for Parkinson's Disease, a neurodegenerative disease that afflicts 1 million Americans. Unfortunately, levodopa has serious side effects and loses its efficacy over time. Using Sinopia Biosciences's computational drug discovery platform, we identified a small molecule that we subsequently tested and validated in relevant rodent and primate models, providing a unique mechanism for treating Parkinson's Disease. This proposal will complete preclinical drug development for this compound in order to advance to the clinic.
Project Terms:
Affect; inhibitor; Biological Sciences; Biologic Sciences; Bioscience; Life Sciences; Brain; Brain Nervous System; Encephalon; Climacteric; life change; Discrimination; Cognitive Discrimination; Disease; Disorder; Dopamine; Hydroxytyramine; Pharmaceutical Preparations; Drugs; Medication; Pharmaceutic Preparations; drug/agent; Gene Expression; Germany; Half-Life; Human; Modern Man; In Vitro; Levodopa; L-Dopa; Literature; Metabolism; Intermediary Metabolism; Metabolic Processes; Liver Microsomes; Mus; Mice; Mice Mammals; Murine; Neurons; Nerve Cells; Nerve Unit; Neural Cell; Neurocyte; neuronal; Parkinson Disease; Paralysis Agitans; Parkinson; Primary Parkinsonism; Legal patent; Patents; Patients; Drug Kinetics; Pharmacokinetics; Pharmacology; Physicians; Primates; Primates Mammals; Rattus; Common Rat Strains; Rat; Rats Mammals; Rodent; Rodentia; Rodents Mammals; Safety; Surveys; Survey Instrument; Testing; Time; Toxicology; 6-OHDA; 6-hydroxydopamine; Oxidopamine; case report; Case Study; Data Set; dosage; improved; Acute; Chronic; Clinical; Penetration; Phase; Link; Lesion; disability; Funding; Agonist; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Poisoning; MPTP Neurotoxicity Syndrome; MPTP injury; MPTP lesion; MPTP lesioning; MPTP neurotoxicity; MPTP toxicity; MPTP-Induced Parkinsonism; toxic effects of MPTP; MPTP Poisoning; Therapeutic; Exposure to; Machine Learning; machine based learning; Clinic; Pattern; Neurodegenerative Disorders; Degenerative Neurologic Diseases; Degenerative Neurologic Disorders; Nervous System Degenerative Diseases; Neural Degenerative Diseases; Neural degenerative Disorders; Neurodegenerative Diseases; Neurologic Degenerative Conditions; degenerative diseases of motor and sensory neurons; degenerative neurological diseases; neurodegenerative illness; American; Performance; metabotropic glutamate receptor 4; mGluR4; Cognitive deficits; cognitive defects; novel; behavior test; behavioral test; Positioning Attribute; Position; Gene Expression Profiling; Gene Expression Monitoring; Gene Expression Pattern Analysis; Transcript Expression Analyses; Transcript Expression Analysis; analyze gene expression; gene expression analysis; gene expression assay; transcriptional profiling; Modeling; Property; response; drug discovery; Neural Stem Cell; neural precursor; neural precursor cell; neural progenitor; neural progenitor cells; neuron progenitors; neuronal progenitor; neuronal progenitor cells; neuronal stem cells; neuroprogenitor; nerve stem cell; small molecule; Dose; Symptoms; Data; Preclinical Drug Development; Pre-clinical Drug Testing/Development; Preclinical Drug Testing/Development; pre-clinical drug development; Motor; in vivo; Neuronal Differentiation; Pharmacological Treatment; Cardiac; Adjuvant; Development; developmental; preclinical study; pre-clinical study; Gene Expression Profile; Expression Signature; gene expression pattern; gene expression signature; transcriptional profile; transcriptional signature; elderly patient; older patient; new drug treatments; new drugs; new pharmacological therapeutic; new therapeutics; new therapy; next generation therapeutics; novel drug treatments; novel drugs; novel pharmaco-therapeutic; novel pharmacological therapeutic; novel therapy; novel therapeutics; effective treatment; effective therapy; pre-clinical efficacy; preclinical efficacy; candidate selection; Levodopa dyskinesia; levodopa induced dyskinesia; L-DOPA induced dyskinesia; Secure; cognitive assessment; cognitive testing; cognitive task; symptomatic treatment; treat symptom; symptom treatment; motor symptom; efficacy study; clinical development; pre-clinical development; preclinical development; computing platform; computational platform; side effect; motor behavior; antagonist; antagonism; pre-Investigational New Drug meeting; Pre IND FDA meeting; Pre-IND mtg; pre-IND consultation; pre-IND discussion; pre-IND meeting