Individuals with opioid user disorder (OUD) face both short-term and long-horizon challenges to healthy andproductive decision-making. Recovery, particularly in the setting of MAT (but also more generally), is deeplyaffected by phasic/psychological cravings and impaired long-horizon decision-making. Current cravings-avoidance tools suffer from limited usability and restricted utility in common environmental/social contexts. Inaddition, the majority of introspective or self-control improvement strategies (mindfulness, CBT) are unsuited foruptake during moments of vulnerability, while clinical counseling or peer support suffer from scale/accesslimitations. In response, we propose a field-deployable (mobile smartphone), automated intervention for acutecravings in OUD which simultaneously addresses neurobiological drivers of long-term impulsive decision-making. The innovation ("BoostONE") comprises a system for just-in-time cravings management (Boost-C) andimpulsivity mitigation (Boost-I) and includes a framework for psychometric measurement of executive function foroutcomes tracking. Predicted effects of usage by individuals in MAT will be evaluated in a feasibility study of thevalidated package. We anticipate this Phase I SBIR will provide the foundation for deployment of BoostONE inactive treatment settings and for broader extensions of the underlying technology framework.
Public Health Relevance Statement: PROJECT NARRATIVE
Opioid use disorder (OUD) and related conditions are extremely damaging to individuals and society. Cravings
and impulsivity are key contributors to OUD relapse which remain underserved by current treatments/tools. We
propose to address both key contributors, in parallel, under a common theoretical framework, via a novel
smartphone intervention ("BoostONE").
Project Terms: Affect ; Attention ; Client ; Counseling ; Cues ; Decision Making ; Disease ; Disorder ; Pharmaceutical Preparations ; Drugs ; Medication ; Pharmaceutic Preparations ; drug/agent ; Engineering ; Exercise ; Face ; faces ; facial ; Feasibility Studies ; Formularies ; Foundations ; Goals ; Government ; Incentives ; Insurance Carriers ; Insurers ; Learning ; Memory ; Short-Term Memory ; Immediate Memory ; Shortterm Memory ; working memory ; Motivation ; Persons ; Neurobiology ; neurobiological ; Outpatients ; Out-patients ; Patients ; Periodicity ; Cyclicity ; Rhythmicity ; Psychometrics ; Public Health ; Relapse ; Research ; Resources ; Research Resources ; Sales ; Signal Transduction ; Cell Communication and Signaling ; Cell Signaling ; Intracellular Communication and Signaling ; Signal Transduction Systems ; Signaling ; biological signal transduction ; Social Environment ; social climate ; social context ; socioenvironment ; socioenvironmental ; Societies ; Computer software ; Software ; Technology ; Testing ; Time ; Time Perception ; Traction ; Treatment Protocols ; Treatment Regimen ; Treatment Schedule ; Urine ; Urine Urinary System ; Vision ; Sight ; visual function ; Measures ; Treatment outcome ; Outcome Measure ; Custom ; base ; quality assurance ; improved ; Acute ; Clinical ; Phase ; Medical ; psychologic ; psychological ; Series ; Training ; Individual ; Recovery ; Licensing ; satisfaction ; Measurement ; Self Perception ; Personal awareness ; Self image ; Self view ; self awareness ; self knowledge ; Drug usage ; drug use ; non-opioid analgesic ; non-narcotic analgesic ; non-opiate analgesic ; non-opioid ; non-opioid therapeutics ; nonnarcotic analgesics ; nonopiate analgesic ; nonopioid ; nonopioid analgesics ; uptake ; Educational Intervention ; Education for Intervention ; Instruction Intervention ; Training Intervention ; instructional intervention ; Letters ; Therapeutic ; tool ; Event ; Clinic ; System ; Test Result ; Visit ; directs attention ; directed attention ; experience ; Animal Models and Related Studies ; model of animal ; model organism ; Animal Model ; neural ; relating to nervous system ; novel ; Participant ; Preventative strategy ; Preventive strategy ; Prevention strategy ; self control ; Self-control as a personality trait ; disease recurrence prevention ; disorder recurrence prevention ; recurrence prevention ; relapse prevention ; disorder later incidence prevention ; Impulsivity ; Modeling ; craving ; response ; Intervention Strategies ; interventional strategy ; Intervention ; executive control ; executive function ; Cell Phone ; Cellular Telephone ; iPhone ; smart phone ; smartphone ; Cellular Phone ; distraction ; Address ; Adherence ; Data ; Cognitive ; Small Business Innovation Research Grant ; SBIR ; Small Business Innovation Research ; Validation ; Process ; active method ; active technique ; active treatment ; Pathway interactions ; pathway ; cost ; neurobehavioral ; digital ; design ; designing ; efficacy evaluation ; efficacy analysis ; efficacy assessment ; efficacy examination ; evaluate efficacy ; examine efficacy ; Treatment Efficacy ; intervention efficacy ; therapeutic efficacy ; therapy efficacy ; Outcome ; Population ; innovation ; innovate ; innovative ; Impairment ; usability ; primary outcome ; successful intervention ; mindfulness ; cloud software ; Executive Dysfunction ; Executive Function Deficit ; Executive Impairment ; peer support ; opioid use disorder ; opiate use disorder ; opioid therapy ; opiate therapy ; smartphone Application ; Android App ; Android Application ; Cell Phone Application ; Cell phone App ; Cellular Phone App ; Cellular Phone Application ; Smart Phone App ; Smart Phone Application ; Smartphone App ; iOS app ; iOS application ; iPhone App ; iPhone Application ; patient engagement ; participant engagement ; opioid user ; Opiate user ; Opioid drug user ; PWUO ; people who use opioids ; persons who use opioids ; Hyperactivity ;
