The NIRSense platform is a silicone-encapsulated wearable device that measures tissue oxygenation in real time using near infrared spectroscopy (NIRS). The device is wirelessly charged and able to toggle wireless communications on and off for secure autonomous operation in the field. A version of the NIRSense hardware is currently under development for physiological monitoring in tactical aircraft. This proposal explores feasibility of using a modified version of the NIRSense hardware to monitor tissue oxygenation in the military operational environment in a robust, low power, and secure wearable device. Tissue oxygenation has significant value as an early indicator of health status, particularly helpful in emergency medicine where rapid decision making is required, often with limited information. Continuously tracking StO2 can better inform medical decision making in both critical and chronic care, as well as remote patient monitoring, rehabilitation, and training optimization during recovery. Current StO2 tools are expensive and not suitable for out-of-clinic use. FDA-approved tools such as the Medtronic INVOS, the Nonin Equanox, and the Edwards Lifesciences FORE-SIGHT are desktop-sized devices with multiple cables and expensive consumables. An easily interpreted wearable device robust enough for the out-of-clinic environment would add significant value for clinical decision assistance en route and near the point of injury.