
Enabling Membrane Protein Structural Analysis: Tools For Capillary Diffusion Crystallization And Remote In Situ Diffraction ExperimentsAward last edited on: 1/22/2021
Sponsored Program
STTRAwarding Agency
NIH : NIGMSTotal Award Amount
$239,206Award Phase
1Solicitation Topic Code
-----Principal Investigator
Richard Howells JrCompany Information
Phase I
Contract Number: 1R41GM139420-01Start Date: 9/7/2020 Completed: 3/6/2021
Phase I year
2020Phase I Amount
$239,206Public Health Relevance Statement:
Project Narrative This research directly addresses the ability to carry out structure-based drug design targeting macromolecules, through development of a means to grow protein crystals and carry them through to X-ray diffraction analysis without ever having to physically touch them. The methods to be developed are proposed to be applicable to both soluble and integral membrane proteins, with diffraction data being collectable either in situ and remotely at either room or cryogenic temperatures and with full rotational access.
Project Terms:
Address; Alabama; Automation; base; beamline; Binding; Blood capillaries; Caliber; Centrifugation; Collection; commercial application; Communities; cryogenics; Crystallization; Crystallography; Data; data access; Data Analyses; Data Collection; design; Development; Devices; Diffuse; Diffusion; Drug Design; Ensure; experience; experimental study; Goals; Growth; Head; Image; imaging system; improved; In Situ; Infrastructure; Integral Membrane Protein; Laboratories; Ligand Binding; Ligands; Lipids; macromolecule; Materials Testing; Membrane Proteins; Methodology; Methods; Optics; Outcome; Output; Partner in relationship; Phase; Positioning Attribute; Preparation; Procedures; Process; Proteins; Research; research and development; Robot; Robotics; Rotation; Sales; Sampling; Secure; Ships; Source; structural biology; Structure; success; synchrotron radiation; Synchrotrons; System; Technology; Temperature; Testing; tool; Toothpaste; Touch sensation; transmission process; Universities; Viscosity; Visual; Work; X ray diffraction analysis
Phase II
Contract Number: ----------Start Date: 00/00/00 Completed: 00/00/00