Highland Instruments is a medical device company structured around development of ESStim™, a noninvasive electrosonic brain stimulation technology for the treatment of chronic pain management. Founded by researchers trained at Harvard Medical School and MIT, Highland Instruments is addressing treatment of osteoarthritis patients suffering from chronic pain and of patients with brain-based movement disorders. Chronic pain of OA is characterized by a phenomenon known as central sensitization, whereby the brain adapts to become more receptive to pain signals generated in the periphery. Highland is focused on implementing ESStim™ noninvasively to treat patients suffering from chronic osteoarthritis pain by stimulating their brain and blocking the processing of the pain signal and central sensitization.