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SBIR-STTR Award
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SBIR-STTR Award
9
IGF OT IGF Title SBIR Phase I Vita Cap Tube to Preserve Circulating Tumor Cells in Blood Pop
Award last edited on: 7/24/20
Sponsored Program
SBIR
Awarding Agency
NIH : NCI
Total Award Amount
$1,952,181
Award Phase
1
Solicitation Topic Code
NCI
Principal Investigator
Helen N Wesley
Company Information
Vitatex Inc
25 Health Sciences Drive Suite 220
Stony Brook, NY 11790
(631) 444-8482
info@vitatex.com
www.vitatex.com
Location:
Single
Congr. District:
01
County:
Suffolk
Phase I
Contract Number:
261201500011C-2-0-0
Start Date:
00/00/00
Completed:
00/00/00
Phase I year
2015
Phase I Amount
$1,952,181
Recent studies show that proliferative and invasion competent circulating tumor cells CTCs are invaluable in many downstream applications that depend on the ability of the isolated tumor cells to recapitulate tumor growth and metastasis in xenograft mouse models The long term objective of this proposal is to convert the existing Vitatex CTC preparation tube to a closed vacutainer system that is capable of collecting blood as well as preserving and immobilizing proliferative and invasion competent cancer cells in blood for up to hours of transit This Phase I proposal aims to identify the cocktail of survival factors for captured CTCs in an experimental spiking setting using blood of healthy women develop SOP methods for isolating CTCs in blood of ovarian cancer patients within vacutainer adapted tubes to analyze for recovery viability and function and assess proliferative and invasive capabilities of isolated CTCs using MTT ATP determination and collagen uptake and spherogenic assay to determine tumorigenicity The goal is to define conditions that promote the survival of tumor cell populations in blood that retain some degree of proliferative capacity Viable CTCs isolated using such methods can then be used ex vivo for selection of treatment tailored to individual patients
Phase II
Contract Number:
----------
Start Date:
00/00/00
Completed:
00/00/00
Phase II year
----
Phase II Amount
----
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