Structured around ALS gene discovery, QurAlis - a current resident of JLab Cambridge MA. - is coming at the task from the perspective of digging deep into the root causes of the multiple sub-forms of this destructive disease - tackling specific disease-causing mechanisms. A LS is aterminal disease that causes muscle paralysis through degeneration of the motor system. It is clearly understood that, with some 30 different genes having been identified as potentially causing development of the disease, many different causes underlie ALS . Recent insights from genetics and new biomarkers suggest clearly that ALS is not one disease, but a spectrum of disorders with varying underlying mechanisms. Anchored in the core task of ALS gene discovery, QurAlis is tackling the problem by digging deep into the root causes of the multiple sub-forms of this destructive disease - tackling specific disease-causing mechanisms, Currently resident in the JLab facility in Cambrige MA., QurAlis was founded to leverage these emerging insights and new stem cell and electrophysiology technologies as th emeans whereby to address curing ALS through the development of oral drugs. When one or more of these genes are not working well, the need is to develop very specific therapeutics to restore the cells to a healthy state to include understanding the link between genetics and disease in ALS and other neurological diseases .