New advances in histology and imaging technology have dramatically increased access to the intricate three-dimensional structure of the brain and other complex organs. Addressing the objective of providing researchers and clinicians with fast, reliable and complete 3D analysis of their biological samples. Having particular expertise in tissue clearing, the principals of Translucence have established a powerful workflow that combines the firm's Mesoscale Imaging System, the pipeline for computational 3D reconstruction and machine learning-based image analysis.