The performance of many x-ray imaging systems is limited by the lack of x-ray detectors with simultaneous high quantum efficiency and high spatial resolution. As examples, digital mammography scanners typically have a resolution of ⥠70 µm for high quantum efficiency, which is not sufficient to effectively detect small but critical microcalcifications. X-ray micro-CT scanners either use high quantum efficiency, low spatial resolution detectors together with high geometric magnification or use high spatial resolution, low quantum efficiency detectors with thin scintillators, which significantly limits the scan throughput. The low-resolution (typically ~ 100 µm) of commercial large area x-ray flat panel detectors made single-shot x-ray phase contrast imaging system not appropriate for most applications since the resolution is determined by the fringe period and has to be at least a few pixels. Research in pixelated scintillators during the last two decades have demonstrated pixel size determined spatial resolution. However, the light guiding (output) efficiency is very low (typically < 10%), which limits the practical application of such detectors in low dose medical x-ray diagnosis. The proposed research in this SBIR Phase I project will focus on developing high light guiding efficiency pixelated scintillators with specially designed and engineered sidewall surface reflectors of the pixels. The spatial resolution defined by the pixel size (down to 15 µm) and the light guiding efficiency comparable to commercial phosphor screens of the same thickness are to be demonstrated. General Optics proposes to bring such high efficiency pixelated scintillators to the market through Phase I research. The specific aims are: (1) develop processes to fabricate 30-µm and 15-µm pitch, up to 200 µm depth silicon pixel wells with â 1 µm wall thickness, and engineer the sidewall surface for high reflectivity; (2) fill the wells with scintillator materials of CsI (Tl) and Gd2O2S:Tb; (3) Test the performance of the fabricated pixelated scintillators and compare them with commercial phosphor screens. Integration of the pixelated scintillators to large area CMOS cameras for fully integrated, large area x-ray detectors would be the next stage of this SBIR Phase I project.
Public Health Relevance Statement: PROJECT NARRATIVE Developments of x-ray detectors with high quantum efficiency and high spatial resolution simultaneously will have immediate impact on numerously x-ray imaging systems, such as digital mammography and dental imaging to improve diagnosis sensitivity, specificity and precision. Pixelated scintillators developed during the last two decades achieved high spatial resolution defined by the pixel size but with very low light output efficiency. The goal of this project is to advance high spatial resolution pixelated scintillators toward practical medical diagnosis and biomedical imaging applications by boosting the quantum efficiency to comparable to commercial high quantum efficiency low resolution scintillator screens through addressing the challenge in guiding the secondary, visible photons out of the scintillator pixels.
Project Terms: Address; Area; bioimaging; breast imaging; Breast Microcalcification; Communities; contrast imaging; Crystallization; Dental; design; detector; Development; Diagnosis; Diagnostic radiologic examination; Digital Mammography; Dose; Engineering; Evaluation; evaporation; experience; Film; Frequencies; Goals; Government; Image; imaging system; improved; innovation; Light; Measures; Medical; melting; Metals; microCT; Needles; Optics; Output; Performance; performance tests; Persons; Phase; Photons; practical application; Process; prototype; quantum; Refractive Indices; Research; Resolution; Roentgen Rays; Scanning; Sedimentation process; Sensitivity and Specificity; Silicon; simulation; Small Business Innovation Research Grant; Structure; Surface; Testing; Thick; Thin
