Proposed herein are novel design methodologies to create sensors for chemical, biological, radiological, nuclear and/or explosive (CBRNE) detection aboard a Small Unmanned Aerial System (SUAS), as well as intelligent Bayesian-based plume analysis and source detection algorithms that offer capabilities for the Air Force above and beyond the state of the art.The assembled technical team of experts from NevadaNano and the University of Utah Robotics Center has a history of collaborating in the area of SUAS-compatible sensor design, development, and deployment to ensure successful project outcomes and deliverables. Sensor designs will leverage both NevadaNanos sensor selection and design experience as well as the teams successful track record with the Molecular Property Spectrometer (MPS)a robust, low-cost, silicon-chip-based sensor platform. We will develop a concept of operations, a conceptual design document, and predict sensor performance in simulated plumes using novel source detection algorithms.Sensor,Plume,CBRNE,SUAS,UAV,algorithm,Bayesian,design