Tierra Biosciences - fdba Synvitrobio - is accelerating bio-discovery through cell-free systems combined with powerful automation tools for data generation: identifying novel molecules from nature using a cell-free discovery platform. Perfecting the science of cell-free systems - starting from technology originally developed at Caltech and backed by DARPA - the firm are employing cell-free systems to enable combinatoric protein expression that is completely ex vivo. The firm notes on its site that 3 things can be easily varied using Tierra technology that is difficult when using cells: (1)Different DNA variants of the input can be produced and expressed in parallel. (2) Cell-free systems: the firm has multiple cell-free systems representing the diversity of life, spanning gram-positive, gram-negative, and eukaryotic species. (3) Modifications: Known additives to the system, such as cofactors or salts, can be supplemented. The end product is not only physical protein, but also multiple layers of rich and actionable data that informs the protein expression workflow.
