We are developing nanoscale electronic circuits (nanofids) that will be implanted into millions of neurons to record neural activity during behavior. Our long-term goal is to record high-resolution neural activity information during acquisition and expression of learned behavioral models of addiction. The long-term health goal is to identify neuronal ensembles encoding addiction-related memories for eventual ablation. In this application, we are developing semiconductor chip prototypes that will transmit near-infrared (NIR) signals with unique frequency identification whenever intracellular calcium levels rise above a set threshold corresponding to neural activation. We are assessing power requirements and biocompatibility of the overall circuit and individual circuit components in air and intracellular model solutions. Signal attenuation of NIR output will be assessed in these solutions using NIR spectrometry. In future, the optimized circuit from this application will be incorporated into millions of devices that will be implanted into neurons for intracellular recordig of neural activity in brain during behavior.
Thesaurus Terms: Ablation;Addiction;Air;Animal Model;Animals;Association Learning;Attenuation;Base;Behavior;Behavioral Model;Biomaterial Compatibility;Biomedical Engineering;Brain;Calcium;Calcium Binding;Calmodulin;Capsid;Capsid Proteins;Cathodes;Cells;Characteristics;Cofactor;Computer Analysis;Cues;Design;Detector;Devices;Electron Transport;Electronics;Electrons;Energy-Generating Resources;Enzymes;Evaluation;Flavin Mononucleotide;Flavin-Adenine Dinucleotide;Frequencies (Time Pattern);Fright;Future;Goals;Government;Health;Human;Imaging Modality;Implant;Individual;Laccase;Learned Behavior;Learning;Marketing;Mediating;Memory;Memory Encoding;Microelectrodes;Modeling;Nadp;Nanoscale;National Institute Of Drug Abuse;Near-Infrared Spectroscopy;Neuronal Patterning;Neurons;Nitric Oxide Synthase;Output;Oxidoreductase;Pattern;Perception;Persons;Pharmaceutical Preparations;Play;Post-Traumatic Stress Disorders;Power Sources;Problem Solving;Process;Prototype;Quantum Dots;Radio;Relating To Nervous System;Research;Resolution;Role;Scale Up;Semiconductors;Signal Transduction;Solutions;System;Technology;Viral;Voltage;
