The BioCurrents Research Center is a resource of the National Institutes of Health (NIH), part of the Biomedical Technology division of the NCRR. As with all Biomedical Technology resources it has two main goals: * To research and develop new biomedical technologies (Center activities). * To make specialized technologies available to visiting biomedical investigators (application for Center use). The emphasis of the BRC is on the physiology of cellular transport mechanisms, particularly as they influence the boundary conditions in the media adjacent to the plasma membrane. To this end we develop new microsensor technologies that operate in a self-referencing mode. We offer access to ion-selective, electrochemical and biosensor devices, coupled to advanced imaging techniques and electrophysiological approaches, combinations unique to the BRC (Center technology). The BioCurrents Research Center is a member of the MBL Program in Molecular Physiology. Participating members of the MP program include the following groups: * Laboratory of Metabolic Diseases * Laboratory for Reproductive Medicine * Laboratory of Robert Greenberg * Laboratory of Peter J.S. Smith. In addition, with instrumentation as a central component, the BRC interacts with the Architectural Dynamics in Living Cells Program. The Center also supports an extensive outreach program to regional and national universities, medical schools and hospitals. In collaboration with our numerous visitors, the BRC has published extensively in the field of cellular transport. Our papers are listed in these web pages. For a more detailed background of the BRC see: History.