
Sequencing by Transcription Using Single-Molecule Field-Effect TransistorsAward last edited on: 3/28/16
Sponsored Program
SBIRAwarding Agency
NIH : NHGRITotal Award Amount
$499,537Award Phase
2Solicitation Topic Code
-----Principal Investigator
Theofilos KotseroglouCompany Information
Phase I
Contract Number: 1R43HG007871-01Start Date: 8/1/14 Completed: 7/31/16
Phase I year
2014Phase I Amount
$250,000Thesaurus Terms:
Address;Architecture;Base;Benchmarking;Biological Assay;Carbon Nanotubes;Cells;Claw;Clinical;Color;Commercialization;Complex;Cost;Data;Design;Design And Construction;Detection;Development;Devices;Diagnostic;Dna;Dna Sequence;Dna-Directed Rna Polymerase;Electronics;Ensure;Enzyme Kinetics;Enzymes;Escherichia Coli;Fluorescence;Genes;Genetic Transcription;Genome;Genome Sequencing;Genomics;Goals;Grant;Housing;Human Genome;Individual;Label;Lead;Length;Measurement;Medicine;Methods;Metric;Microbial;Molecular Conformation;Monitor;Motion;Mutant;Nanopore;Nanotubes;Nucleotides;Optics;Performance;Phase;Point-Of-Care Diagnostics;Positioning Attribute;Preparation;Prevent;Programs;Promotor (Genetics);Prototype;Public Health Relevance;Reading;Research;Resolution;Reverse Transcription;Rna;Sampling;Screening;Series;Signal Transduction;Single Molecule;Staging;Statistics;Surface;System;Technology;Time;Transistors;Translating;Work;
Phase II
Contract Number: 5R43HG007871-02Start Date: 8/1/14 Completed: 7/31/16
Phase II year
2015Phase II Amount
$249,537Public Health Relevance Statement:
Public Health Relevance:
Currently there are several commercial and under development DNA sequencing systems and although improvements in cost per base and cost for whole human genome have been tremendous, the goal of doing this with appropriate accuracy under $1,000 has not yet been achieved. To address this, Eve Biomedical proposes to develop a compact DNA sequencing system that will be able to sequence the whole human genome under $100 i.e. an order of magnitude less than the target and including sample preparation and with the cost of goods of the system well under $5,000. It will break the barrier to introducing sequencing in clinical diagnostics and jump start the era of genomic medicine.
NIH Spending Category:
Bioengineering; Biotechnology; Genetics; Human Genome; Nanotechnology
Project Terms:
Address; Architecture; base; Benchmarking; Biological Assay; Carbon Nanotubes; Cells; Claw; Clinical; Color; commercialization; Complex; cost; Data; design; design and construction; Detection; Development; Devices; Diagnostic; DNA; DNA Sequence; DNA-Directed RNA Polymerase; ds-DNA; Electronics; Ensure; Enzyme Kinetics; Enzymes; Escherichia coli; Fluorescence; Genes; Genetic Transcription; Genome; Genomics; Goals; Grant; Health; Housing; Human Genome; human genome sequencing; Individual; Label; Lead; Length; Measurement; Medicine; Methods; microbial; Molecular Conformation; Monitor; Motion; mutant; nanopore; Nanotubes; Nucleotides; Optics; Performance; Phase; point-of-care diagnostics; Positioning Attribute; Preparation; prevent; programs; Promotor (Genetics); prototype; Reading; Research; Resolution; Reverse Transcription; RNA; Sampling; screening; Series; Signal Transduction; single molecule; Staging; statistics; Surface; System; Technology; temporal measurement; Time; Transistors; Translating; Work