Date: Nov 11, 2013 Author: Emily Cukier-Meisner Source: Biocentury.com (
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SphynKx Therapeutics LLC is developing a portfolio of sphingosine kinase inhibitors that can up- or down-regulate blood levels of sphingosine 1-phosphate to treat fibrosis in different organs.
The company's lead program focuses on preventing fibrosis in chronic kidney disease by increasing circulating sphingosine 1-phosphate (S1P). A less advanced program seeks to treat idiopathic pulmonary fibrosis (IPF) by lowering S1P.