Chem-bio attacks are a threat to U.S. military personnel and civilians. While there exist field detection assays and associated mobile readers, it remains imperative to develop next-generation readers that are location-aware, multi-format, and cellular-capable. A compelling platform that has already led to several next-generation readers is smartphones and tablets. These devices provide key elements of a mobile reader: camera; touch screen; processor; storage; battery; firmware; operating system; and wireless connectivity. They are inexpensive and ubiquitous, and will continue to advance rapidly. During Phase I, Celadon (Hyattsville, MD) and its partner, Mobile Assay (Boulder, CO), will demonstrate that the Mobile Assay TrackerTM app for iOS and Android is superior to visual detection; that it meets or exceeds all other Phase I requirements; that it can quantify results; and that it can play an important role in chem-bio surveillance. In addition, we will configure Celadon's clinical immunoassay software, ImmunoFITTM, for Phase I assays and receipt of assay results from the Mobile Assay app. The Phase II plan is to implement all required features; configure TrackerTM and ImmunoFITTM for chem-bio assays; and enhance the system so that end-users are able to configure new assays without software programming