
Multi-Targeted Countermeasures Against Acute And Delayed Effects Of Op ExposureAward last edited on: 9/11/13
Sponsored Program
SBIRAwarding Agency
NIH : NIEHSTotal Award Amount
$374,488Award Phase
1Solicitation Topic Code
-----Principal Investigator
John A ButeraCompany Information
Phase I
Contract Number: 1R43ES023773-01Start Date: 8/20/13 Completed: 7/31/14
Phase I year
2013Phase I Amount
$374,488Public Health Relevance Statement:
Public Health Relevance:
Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure NARRATIVE Organophosphate (OP) nerve agents have been stockpiled and deployed as weapons of mass destruction. While originally developed as pesticides in the 1930's, their potent effects on the central nervous system (CNS) led to their optimization / large-scale production and their addition to the chemical arsenals of military organizations and extremist groups throughout the world. The classic OP nerve agents such as sarin, soman, tabun, and VX, along with related OP pesticides, represent some of the most toxic materials known to humankind. Their principal mechanism of action involves inhibition of acetylcholinesterase (AChE) which normally hydrolyses acetylcholine in the synapse. This synaptic "flooding" of acetylcholine results in an excitotoxic sequelae including seizures, muscle paralysis, mucous secretions, irritation, blurry vision, cardiorespiratory depression, loss of consciousness, and either immediate or eventual death as a result of progressive neurodegeneration. Intentional or accidental misuse of these agents leads to approximately 2 million cases of OP exposure per year worldwide; resulting in several hundred thousand deaths per year. Currently available countermeasures for OP poisoning are woefully inadequate and involve the administration of a "triple cocktail" including an anticholinergic agent, a benzodiazepine anticonvulsant agent, and an oxime agent which can re-activate the inhibited AChE. However, the well-documented long-term secondary neuronal damage that results from initial exposure to OP poisons is not addressed by the current countermeasures. Therefore, it is the aim of this project to discover novel and mechanistically unique dual-acting agents which could represent a breakthrough innovative countermeasure against OP chemical threats that includes treatment of acute OP-poisoning and mitigation of long-term neurodegenerative effects.
Project Terms:
Acetylcholine; Acetylcholinesterase; Acetylcholinesterase Inhibitors; Acute; Address; Anti-Cholinergics; Anticonvulsants; Anxiety; Attenuated; Axon; base; Benzamides; Benzodiazepines; Binding (Molecular Function); Blood; Blood - brain barrier anatomy; Brain Injuries; Cardiac; central nervous system injury; Cessation of life; Charge; Chemicals; cholinergic; Cleaved cell; Clinical; Cognitive deficits; Demyelinations; design; Diabetes Mellitus; Disease; Distress; Dose; drug development; drug discovery; Drug Interactions; Drug Kinetics; drug market; emergency service/first responder; Emotional Disturbance; Equilibrium; excitotoxicity; experience; Exposure to; Eye; Floods; Free Radical Formation; Freedom; Generations; Goals; Grant; Health Personnel; Hemorrhagic Shock; Hydrolysis; improved; In Vitro; in vivo; Inflammation; inhibitor/antagonist; innovation; Intellectual Property; Intoxication; irritation; Ischemia; Kinetics; knowledge base; large scale production; late disease onset; Late-Onset Disorder; Lead; Learning Disabilities; Libraries; Ligands; Link; Malignant Neoplasms; Measures; Mental Depression; Metabolism; Metric; Military Personnel; Mind; Mitochondria; Modality; Molecular Target; Mucous body substance; Muscarinic Acetylcholine Receptor; Muscle; National Institute of Neurological Disorders and Stroke; Nature; Nerve; nerve agent; Nerve Degeneration; nervous system disorder; Neuraxis; Neurons; Neuropathy; neuroprotection; Neuroprotective Agents; neuropsychiatry; Niacinamide; Nicotinic Receptors; novel; organophosphate poisoning; Organophosphates; Oxidative Stress; Oximes; Paralysed; Parents; Pathway interactions; Penetration; Permeability; Pesticides; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmacologic Substance; pharmacophore; Phase; pill (pharmacologic); Play; Poly(ADP-ribose) Polymerases; Post-Traumatic Stress Disorders; pre-clinical; Process; progressive neurodegeneration; Property; prototype; public health relevance; Rattus; receptor; Reporting; response; Risk; Rodent Model; Safety; Sarin; scaffold; screening; Seizures; Series; Serine; Site; Small Business Innovation Research Grant; Small Business Technology Transfer Research; small molecule; Soman; Staging; Status Epilepticus; stroke; Synapses; Syndrome; tabun; Terrorism; Therapeutic; tool; Toxic effect; toxic organophosphate insecticide exposure; Toxin; Treatment outcome; Unconscious State; United States National Institutes of Health; Vision; weapons of mass destruction; Work
Phase II
Contract Number: ----------Start Date: 00/00/00 Completed: 00/00/00