In this application, we propose to conduct research to advance our patented technologies that identify early evidence of cardiovascular (CV) injury upon the receipt of cardiotoxic chemotherapy for breast cancer patients. For these patients, the prevalence of cardiovascular events including heart failure (HF) is 18% - 22%, and represents the second leading cause of morbidity and mortality. We have identified a method to detect early evidence of myocellular injury which offers opportunities for early treatment so that these patients avoid permanent myocardial damage that causes HF. In this study, we propose to: 1) determine the utility of our analyses for identifying the myocellular injury associated with administration of doxorubicin. 2) determine the utility of our results to forecast future changes i left ventricular ejection fraction (LVEF) upon receipt of doxorubicin chemotherapy, and 3) determine the association between our results, LVEF and serum Troponin after receipt of doxorubicin chemotherapy. The results of this proposal will provide the data that is needed to develop this analytic model for the product that identifies the breast cancer patients who are the most susceptible to myocardial injury and LV dysfunction such that targeted interventions can be started to reduce the impact of these CV events. For these patients, our product will provide an integrated system of quantitative and longitudinal tracking of CV injury. In the future, this product can be scaled to include other patient populations in need of surveillance for cardiomyopathy such as, other cancer survivors, diabetics, the obese, and patients with viral infections.
Public Health Relevance Statement: Public Health Relevance: In this application, we propose to advance the use of our novel imaging analysis tool so that breast cancer patients, who have suffered cardiovascular injury from their chemotherapy treatments, can be identified early, when their injury is still treatable. Cardiovascular injury is the second leading cause of morbidity and mortality for these women; however, if these patients are treated for their cardiovascular injuries before they develop heart failure their prognosis is greatly improved. In the future, this product can be expanded to include other patient populations in need of surveillance for early cardiac injury, such as, childhood and prostate cancer survivors, alcoholics, diabetics, the obese, and patients with HIV or other viral infections.
Project Terms: Activities of Daily Living; Adjuvant; Adjuvant Chemotherapy; Age; Algorithms; animal data; Animal Model; Animals; Anthracyclines; base; Biological Markers; Breast Cancer Treatment; Cancer Patient; Cancer Survivor; cancer therapy; Cardiac; Cardiomyopathies; Cardiotoxicity; cardiovascular imaging; cardiovascular injury; Cardiovascular system; chemotherapy; Clinical; Cohort Studies; Comorbidity; Control Groups; Data; Detection; Deterioration; diabetic; diabetic patient; Dose; Doxorubicin; Early treatment; Event; Exposure to; Fees; Fibrosis; forest; Functional disorder; Future; Gadolinium; gadolinium oxide; Goals; Health Sciences; Heart failure; HIV; Human; Hypertension; Image; Image Analysis; improved; Injury; Intervention; Ionizing radiation; Left Ventricular Ejection Fraction; Legal patent; Link; Magnetic Resonance Imaging; malignant breast neoplasm; Malignant Childhood Neoplasm; Malignant neoplasm of prostate; Malignant Neoplasms; Maps; Measures; Methods; Metric; Modeling; Morbidity - disease rate; Mortality Vital Statistics; Muscle function; Myocardial; Myocardial Infarction; Myocardium; novel; Obesity; older women; outcome forecast; patient population; Patients; Performance; Phase; Physicians; Prevalence; prevent; problem drinker; Procedures; Process; public health relevance; Reporting; Research; Rest; Saline; Scanning; Schedule; Secure; Sensitivity and Specificity; Serum; Services; Site; Survivors; survivorship; System; Techniques; Technology; Time; tool; Translating; Troponin; tumor; Universities; Virus Diseases; Woman; Women's Group; young woman
