SBIR-STTR Award

More than 1000 American die every single day due to sudden cardiac arrest (SCA), which claims more lives than breast cancer, AIDS, and lung cancer combined. The survival from SCA strongly depends on the early defibrillation and the probability of survival decreases by 7-10% for every minute of delay in defibrillation. In fact, less than 5% of patients with out-of-hospital SCA can survive to hospitalization. It has been found that automated external defibrillators (AED) can at least double the overall survival rate for out-of-hospital cardiac arrest patients. In this fast-track SBIR program, Strategic Polymer Sciences, Inc. (SPS) proposes to develop low-cost compact film capacitors with ultra-high electrical energy density for portable AED. The advanced capacitors will utilize the recent breakthrough dielectric materials discovered at Penn State University (Zhang et al. Science 280:2101; 313:334; 321:821; & Nature 419:284) and the commercial-scale resin production and thin film processing technologies developed by SPS. For the same amount of delivered energy, the SPS capacitors will be 80% smaller and 50% cheaper than the current polypropylene (PP) AED capacitors. The advanced SPS film capacitors will shrink the size and reduce the cost of AED, facilitate the deployment of AED in millions of American homes and public buildings, and save thousands of patients with heart arrhythmia problem.

Public Health Relevance:
The development of ultra-high energy density capacitors based on advanced SPS dielectric materials can significantly reduce the size and cost of Automated External Defibrillators (AED). This will enable the deployment of AED in millions of homes of patients with heart arrhythmia problem who are facing the threat of delayed defibrillation if AED not available.

Thesaurus Terms:
Aids; Acquired Immune Deficiency; Acquired Immune Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immunodeficiency Syndrome; Am 80; Am80; American; Area; Armed Forces Personnel; Arrhythmia; Asystole; Automated External Defibrillator; Benchmarking; Benzoic Acid, 4-(((5,6,7,8-Tetrahydro-5,5,8,8-Tetramethyl-2-Naphthalenyl)Amino)Carbonyl)-; Best Practice Analysis; Cancer Of Breast; Cancer Of Lung; Cardiac Arrest; Cardiac Arrhythmia; Cardioversion; Charge; Community Trial; Computer Simulation; Computerized Models; Contracting Opportunities; Contracts; Dod; Defect; Defibrillation, Electric; Defibrillators; Department Of Defense; Development; Devices; Electric Countershock; Electric Shock Cardiac Stimulators; Electronics; Electroversion, Cardiac; Electroversions, Cardiac; Evaluation; Event; Figs; Figs - Dietary; Film; Generations; Government; Hosp; Heart Arrest; Heart Arrhythmias; Home; Home Environment; Hospitalization; Hospitals; Immunologic Deficiency Syndrome, Acquired; Investments; Legal Patent; Licensing; Life; Life Cycle; Life Cycle Stages; Malignant Tumor Of The Breast; Malignant Tumor Of The Lung; Malignant Neoplasm Of Breast; Malignant Neoplasm Of Lung; Manufacturer; Manufacturer Name; Marketing; Mathematical Model Simulation; Mathematical Models And Simulations; Mechanics; Medical; Military; Military Personnel; Models, Computer; Msec; National Heart, Lung, And Blood Institute; Nature; O Element; O2 Element; Oxygen; Patents; Patients; Performance; Persons; Phase; Plant Resins; Polymers; Polypropylenes; Probability; Process; Production; Programs (Pt); Programs [publication Type]; Propene Polymers; Property; Property, Loinc Axis 2; Propylene Polymers; Publishing; Pulmonary Cancer; Pulmonary Malignant Neoplasm; Qol; Quality Of Life; Research Resources; Resins, Plant; Resources; Rheology; Sbir; Sbirs (R43/44); Saint Jude Children's Cancer Center; Saint Jude Children's Research Hospital; Sales; Science; Simulation, Computer Based; Small Business Innovation Research; Small Business Innovation Research Grant; Speed; Speed (Motion); St. Jude; St. Jude Children's Cancer Center; St. Jude Children's Research Hospital; St.Jude Children's Cancer Center; St.Jude Children's Research Hospital; Stimulators, Electrical, Cardiac, Shock; Surface; Survival Rate; Technology; Testing; Thick; Thickness; Time; Universities; V (Voltage); Work; Base; Commercialization; Computational Modeling; Computational Models; Computational Simulation; Computer Based Models; Computerized Modeling; Computerized Simulation; Cost; Defibrillation; Design; Designing; Electric Countershock Heart Resuscitation; Energy Density; Fundamental Research; Improved; In Silico; Life Course; Lung Cancer; Malignant Breast Neoplasm; Millisecond; Nano Particle; Nanoparticle; Processing Speed; Programs; Prototype; Public Health Relevance; Resin; Scale Up; Virtual Simulation; Voltage

More than 1000 American die every single day due to sudden cardiac arrest (SCA), which claims more lives than breast cancer, AIDS, and lung cancer combined. The survival from SCA strongly depends on the early defibrillation and the probability of survival decreases by 7-10% for every minute of delay in defibrillation. In fact, less than 5% of patients with out-of-hospital SCA can survive to hospitalization. It has been found that automated external defibrillators (AED) can at least double the overall survival rate for out-of-hospital cardiac arrest patients. In this fast-track SBIR program, Strategic Polymer Sciences, Inc. (SPS) proposes to develop low-cost compact film capacitors with ultra-high electrical energy density for portable AED. The advanced capacitors will utilize the recent breakthrough dielectric materials discovered at Penn State University (Zhang et al. Science 280:2101;313:334;321:821;&Nature 419:284) and the commercial-scale resin production and thin film processing technologies developed by SPS. For the same amount of delivered energy, the SPS capacitors will be 80% smaller and 50% cheaper than the current polypropylene (PP) AED capacitors. The advanced SPS film capacitors will shrink the size and reduce the cost of AED, facilitate the deployment of AED in millions of American homes and public buildings, and save thousands of patients with heart arrhythmia problem. , ,

Public Health Relevance:
The development of ultra-high energy density capacitors based on advanced SPS dielectric materials can significantly reduce the size and cost of Automated External Defibrillators (AED). This will enable the deployment of AED in millions of homes of patients with heart arrhythmia problem who are facing the threat of delayed defibrillation if AED not available.

Thesaurus Terms:
Aids;Acquired Immune Deficiency;Acquired Immune Deficiency Syndrome;Acquired Immuno-Deficiency Syndrome;Acquired Immunodeficiency Syndrome;Am 80;Am80;American;Area;Armed Forces Personnel;Arrhythmia;Asystole;Automated External Defibrillator;Benchmarking;Benzoic Acid, 4-(((5,6,7,8-Tetrahydro-5,5,8,8-Tetramethyl-2-Naphthalenyl)Amino)Carbonyl)-;Best Practice Analysis;Cancer Of Breast;Cancer Of Lung;Cardiac Arrest;Cardiac Arrhythmia;Cardioversion;Charge;Community Trial;Computer Simulation;Computerized Models;Contracting Opportunities;Contracts;Dod;Defect;Defibrillation, Electric;Defibrillators;Department Of Defense;Development;Devices;Electric Countershock;Electric Shock Cardiac Stimulators;Electronics;Electroversion, Cardiac;Electroversions, Cardiac;Evaluation;Event;Figs;Figs - Dietary;Film;Generations;Government;Hosp;Heart Arrest;Heart Arrhythmias;Home;Home Environment;Hospitalization;Hospitals;Immunologic Deficiency Syndrome, Acquired;Investments;Legal Patent;Licensing;Life;Life Cycle;Life Cycle Stages;Malignant Tumor Of The Breast;Malignant Tumor Of The Lung;Malignant Neoplasm Of Breast;Malignant Neoplasm Of Lung;Manufacturer;Manufacturer Name;Marketing;Mathematical Model Simulation;Mathematical Models And Simulations;Mechanics;Medical;Military;Military Personnel;Models, Computer;Msec;National Heart, Lung, And Blood Institute;Nature;O Element;O2 Element;Oxygen;Patents;Patients;Performance;Persons;Phase;Plant Resins;Polymers;Polypropylenes;Probability;Process;Production;Programs (Pt);Programs [publication Type];Propene Polymers;Property;Property, Loinc Axis 2;Propylene Polymers;Publishing;Pulmonary Cancer;Pulmonary Malignant Neoplasm;Qol;Quality Of Life;Research Resources;Resins, Plant;Resources;Rheology;Sbir;Sbirs (R43/44);Saint Jude Children's Cancer Center;Saint Jude Children's Research Hospital;Sales;Science;Simulation, Computer Based;Small Business Innovation Research;Small Business Innovation Research Grant;Speed;Speed (Motion);St. Jude;St. Jude Children's Cancer Center;St. Jude Children's Research Hospital;St.Jude Children's Cancer Center;St.Jude Children's Research Hospital;Stimulators, Electrical, Cardiac, Shock;Surface;Survival Rate;Technology;Testing;Thick;Thickness;Time;Universities;V (Voltage);Work;Base;Commercialization;Computational Modeling;Computational Models;Computational Simulation;Computer Based Models;Computerized Modeling;Computerized Simulation;Cost;Defibrillation;Design;Designing;Electric Countershock Heart Resuscitation;Energy Density;Fundamental Research;Improved;In Silico;Life Course;Lung Cancer;Malignant Breast Neoplasm;Millisecond;Nano Particle;Nanoparticle;Processing Speed;Programs;Prototype;Public Health Relevance;Resin;Scale Up;Virtual Simulation;Voltage